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EQS-News: Evotec SE / Key word(s): Miscellaneous
Evotec and Variant Bio enter strategic partnership to discover and develop fibrosis treatments
2024-04-18 / 13:27 CET/CEST
The issuer is solely responsible for the content of this announcement.

. COLLABORATION LEVERAGES VARIANT BIO'S CUTTING-EDGE GENOMIC DISCOVERY PLATFORM AND EVOTEC'S INTEGRATED
END-TO-END R&D PLATFORM AND DISEASE AREA EXPERTISE TO ADDRESS UNMET MEDICAL NEED IN FIBROTIC INDICATIONS
. COMMERCIAL TERMS INCLUDE RESEARCH FUNDING AND MILESTONES AND/OR ROYALTY PAYMENTS TO EVOTEC BASED ON THE
OVERALL SUCCESS OF THE PROGRAMME
Hamburg, Germany and Seattle, USA, 18 April 2024:
Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) and Variant Bio, Inc. today
announced a collaboration agreement to identify a best-in-class treatment for diseases caused by fibrosis.
Fibrosis is characterised by marked and pathogenic build-up of the tissue matrix, leading to tissue degeneration in
organs, including the liver and lungs. Fibrotic disease contributes substantially to global mortality and morbidity.
Despite the chronic nature of fibrotic conditions, widespread impact on various organs, and substantial disease burden,
there is currently no curative treatment for these conditions.
The strategic partnership leverages Variant Bio's cutting-edge genomic discovery capabilities and VB-Inference platform
as well as Evotec's extensive expertise in antifibrotic drug discovery. Evotec will identify best-in-class small
molecules targeting a key fibrotic pathway with strong genetic support identified by Variant Bio and progress the
programme towards the selection of a clinical development candidate(s) using Evotec's integrated end-to-end R&D
platform. Additionally, the collaboration includes an opportunity to evaluate unrelated nephrology targets based on
human multi-omics data with Evotec's molecular patient database ("E.MPD").
Under the terms of the risk-sharing partnership, Evotec will receive undisclosed research funding and may receive
pre-clinical and clinical milestones and/or royalties dependent on the success of the programme. This strategic
framework allows Variant Bio to offset the early costs of drug development in exchange for a portion of the future
upside.
Dr Matthias Evers, Chief Business Officer of Evotec, said: "We are excited to enter this collaboration with Variant
Bio. Variant's genomics-focused model which identifies novel drug targets perfectly aligns with Evotec's data-driven
approach to redefine diseases at the molecular level and enhance probability of success. We look forward to combining
our complementary drug discovery platforms in a capital efficient partnership and drive new, best-in-class fibrosis
treatments together."
Andrew Farnum, CEO at Variant Bio, said: "Evotec has established and validated in vitro and in vivo models to
accelerate programme timelines and is ideally positioned to advance our fibrosis programme. They have the experience
and track record in converting breakthrough science into medicines that matter for patients."
Dr David Moller, CSO at Variant Bio, added: "We are thrilled to collaborate with Evotec given their deep expertise in
disease biology and their outstanding drug discovery capabilities that complement Variant Bio's R&D team. These factors
will play a critical role in the success of our pre-clinical and development goals."
ABOUT VARIANT BIO
Variant Bio is developing life-saving therapies by studying the genes of people with exceptional health-related traits.
By identifying communities with unique genetic architectures and outlier phenotypes, Variant Bio has identified novel
human genetic evidence that is the basis for programs with breakthrough potential across multiple therapeutic areas.
The company's research is powered by its proprietary VB-Inference platform, which integrates deep phenotyping and
multi-omics data using statistical genetics and AI/ML approaches to identify and validate therapeutic targets. With
ethics at its core, the company launched an unprecedented benefit-sharing program in 2020, in which it has pledged
tangible benefits that directly impact the communities it partners with throughout the world. Variant Bio is now poised
to advance multiple potentially life-changing therapeutic programs toward the clinic, and to create concomitant value
for partner communities who have entrusted the company with their genetic data. Follow Variant Bio's news and updates
at www.variantbio.com and via its blog, on X/Twitter @VariantBio, on Instagram @variant_bio, and on LinkedIn.
Variant Bio Contacts
Sarah LeBaron von Baeyer, Director of Ethics and Engagement sarah@variantbio.com, www.variantbio.com

ABOUT EVOTEC SE
Evotec is a life science company with a unique business model that delivers on its mission to discover and develop
highly effective therapeutics and make them available to the patients. The Company's multimodality platform comprises a
unique combination of innovative technologies, data and science for the discovery, development, and production of
first-in-class and best-in-class pharmaceutical products. Evotec leverages this "Data-driven R&D Autobahn to Cures" for
proprietary projects and within a network of partners including all Top 20 Pharma and over 800 biotechnology companies,
academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of
currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious
diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative
therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early
discovery to clinical development. Evotec operates globally with more than 5,000 highly qualified people. The Company's
17 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For
additional information please go to www.evotec.com and follow us on X/Twitter @Evotec and LinkedIn.
FORWARD-LOOKING STATEMENTS
This announcement contains forward-looking statements concerning future events, including the proposed offering and
listing of Evotec's securities. Words such as "anticipate," "believe," "could," "estimate," "expect," "intend," "may,"
"might," "plan," "potential," "should," "target," "would" and variations of such words and similar expressions are
intended to identify forward-looking statements. Such statements include comments regarding Evotec's expectations for
revenues, Group EBITDA and unpartnered R&D expenses. These forward-looking statements are based on the information
available to, and the expectations and assumptions deemed reasonable by Evotec at the time these statements were made.
No assurance can be given that such expectations will prove to have been correct. These statements involve known and
unknown risks and are based upon a number of assumptions and estimates, which are inherently subject to significant
uncertainties and contingencies, many of which are beyond the control of Evotec. Evotec expressly disclaims any
obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained
herein to reflect any change in Evotec's expectations with respect thereto or any change in events, conditions or
circumstances on which any statement is based.
Media Contact Evotec SE:
Gabriele Hansen, SVP Head of Global Corporate Communications, Gabriele.Hansen@evotec.com
Hinnerk Rohwedder, Director of Global Corporate Communications, Hinnerk.Rohwedder@evotec.com
IR Contact Evotec SE:
Volker Braun, EVP Head of Global Investor Relations & ESG, Volker.Braun@evotec.com
2024-04-18 CET/CEST Dissemination of a Corporate News, transmitted by EQS News - a service of EQS Group AG.
The issuer is solely responsible for the content of this announcement.
The EQS Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.

Archive at www.eqs-news.com  
Language:     English 
Company:      Evotec SE 

Manfred Eigen Campus / Essener Bogen 7
22419 Hamburg
Germany

Phone:        +49 (0)40 560 81-0 
Fax:          +49 (0)40 560 81-222 
E-mail:       info@evotec.com 
Internet:     www.evotec.com 
ISIN:         DE0005664809 
WKN:          566480 
Indices:      MDAX, TecDAX 
Listed:       Regulated Market in Berlin, Frankfurt (Prime Standard); Regulated Unofficial Market in Dusseldorf, 

Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange; Nasdaq
EQS News ID: 1882961

End of News EQS News Service
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1882961 2024-04-18 CET/CEST

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END) Dow Jones Newswires

April 18, 2024 07:27 ET (11:27 GMT)