Smith+Nephew (NYSE:SNN; LSE:SN), the global medical technology company is
pleased to announce exciting data for its ALLEVYN LIFE Dressing in a recent
study by Professor Amit Gefen and his research group published in the
International Wound Journal,(1) that shows a novel mechanism of action relating
to pressure injury prevention (PIP).
The study found that due to the independent and non-bonded internal layers of
ALLEVYN LIFE Dressing, a layer-on-layer sliding phenomenon occurs and allows for
dissipation of mechanical energy that could otherwise be transferred to the
patient in a bonded dressing.(1)
The results show that layer-on-layer frictional sliding of ALLEVYN LIFE Dressing
absorbs 30-45% of the mechanical energy, which could help alleviate pressure
injury incidence in a patient's skin and underlying soft tissues. This novel
mechanism of action further adds to our understanding of how multi-layer
dressings such as ALLEVYN LIFE work when used prophylactically for PIP.(1)
"Based on my extensive, decades-long research in pressure ulcer/injury
prevention, I am certain that an effective prevention dressing must contain a
shear mitigation mechanism," said Amit Gefen, Professor of Biomedical
Engineering at Tel Aviv University. "My recent study published in the
International Wound Journal on ALLEVYN LIFE Dressing revealed the role of its
unique internal frictional layer-on-layer sliding which, together with its
specific construct and material composition, facilitate effective shear
mitigation."
"Pressure injuries have a high burden on patients and healthcare systems," said
Rohit Kashyap, President, Advanced Wound Management at Smith+Nephew. "This
alignment of the laboratory findings with the clinical literature clearly
demonstrates the enhanced clinical efficacy of ALLEVYN LIFE Dressings in helping
reduce the burden of preventable pressure injuries as one of the only 5-layer
foam dressings with independent, non-bonded layers."
Pressure injuries remain one of the most significant healthcare challenges
globally that affects patients of all ages.(1) On average, a pressure injury
leads to increased healthcare costs of $21,767 per patient and an extra 9.5 days
in hospital.(8)
The study introduced a novel method to thoroughly test the frictional sliding
capabilities of the independent layers of ALLEVYN LIFE Dressing. A new metric,
frictional energy absorber effectiveness (FEAE), was also introduced to quantify
the total mechanical energy dissipation of ALLEVYN LIFE Dressing.(1)
This newly discovered mechanism of action for ALLEVYN LIFE Dressing further
adds, and gives context to, the already existing wealth of clinical evidence(9)
for its capabilities in PIP that demonstrate significant reduction in pressure
injury incidence.(*1)
To read the full publication please click here
(https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.14871). To learn more
about ALLEVYN LIFE Foam Dressings please click here (https://www.smith-
nephew.com/en/health-care-professionals/products/advanced-wound-
management/allevyn-life).

                                    - ends -
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(*)For category II and above pressure injuries, when applied prophylactically in
combination with a standard PIP protocol, versus standard protocols alone
References
1. Marché C, Creehan S, Gefen A. The frictional energy absorber effectiveness

    and its impact on the pressure ulcer prevention performance of multilayer
    dressings. Int Wound J. 2024; 21(4):e14871.

2. Smith+Nephew 2016. Permeability of Hydrophillic Polyurethane Film when in

    contact with water and water vapour (ALLEVYN LIFE). Internal Report.
    RD/16/019.

3. Tiscar-González V, Menor-Rodríguez MJ, Rabadán-Sainz C, et al. Clinical and
Economic Impact of Wound Care Using a Polyurethane Foam Multilayer Dressing. Adv Skin Wound Care. 2021;34(1):23-30.
4. Smith+Nephew 2016. Wound Model Testing of New ALLEVYN Life Gen2 wcl Dressing

    using Horse Serum at a Flow Rate Modelling that of a Moderately Exuding
    Wound. DS/14/303/R

5. Rossington A, Drysdale K, Winter R. Clinical performance and positive impact
on patient wellbeing of ALLEVYN Life. Wounds UK. 2013;9(4):91-95
6. Clarke R. Positive patient outcomes: The use of a new silicone adhesive foam

    dressing for pressure ulcer prevention and treatment. Paper presented at:
    CAET; 2013

7. Lisco C. Evaluation of a new silicone gel-adhesive hydrocellular foam
dressing as part of a pressure ulcer prevention plan for ICU patients. Paper presented at: WOCN; 2013
8. Wassel C, Delhougne G, Gayle J, et al. Risk of readmissions, mortality, and
hospital-acquired conditions across hospital-acquired pressure injury (HAPI)

    stages in a US National Hospital discharge database. Int Wound J.
    2020; 1-11.

9. Smith+Nephew 2021. ALLEVYN Dressing's PIP evidence compendium. 31817.

    Available at: https://smith-
    nephew.stylelabs.cloud/api/public/content/allevyn-dressings-pip-compendium-
    2021?v=f6cfe376

About Smith+Nephew
Smith+Nephew is a portfolio medical technology business focused on the repair,
regeneration and replacement of soft and hard tissue. We exist to restore
people's bodies and their self-belief by using technology to take the limits off
living. We call this purpose 'Life Unlimited'. Our 18,000 employees deliver this
mission every day, making a difference to patients' lives through the excellence
of our product portfolio, and the invention and application of new technologies
across our three global business units of Orthopaedics, Sports Medicine & ENT
and Advanced Wound Management.
Founded in Hull, UK, in 1856, we now operate in more than 100 countries, and
generated annual sales of $5.5 billion in 2023. Smith+Nephew is a constituent of
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