* A Binding LOI has been executed: GEDiCube will acquire 75% of Cyclomics at
Closing.
* Expected breakthroughs by combining technologies in (early) cancer detection and recurrence of cancer with a single vial of blood.
* Cyclomics' 4th generation liquid biopsy genomics platform is the first truly

    "Omni-Omic" blood test ready for AI application.
  * GEDiCube's award-winning AI is developing high-performance biomarker panels
    for 13 different cancers.
  * GEDiCube's partnership with NVIDIA's Inception program will help expand to
    multi-modal capabilities by adding imaging.

The combined Companies aim to Disrupt Cancer Diagnosis and treatment through
early disease and recurrence detection, prediction of response to treatment, and
personalized therapy.
LOS ANGELES and AMSTERDAM, Feb. 15, 2024 (GLOBE NEWSWIRE) -- GEDiCube (moving
forward RenovaroCube), a London and Netherlands-based advanced AI company and a
wholly owned subsidiary of Renovaro Inc. (NASDAQ: RENB), announces it has
executed a binding Letter of Intent (LOI) to acquire 75% of Cyclomics, a Dutch
Company. Under the terms of the LOI, the parties have agreed to work in good
faith on the drafting of a definitive agreement.
Cyclomics has developed a groundbreaking diagnostic method for monitoring early
cancer recurrence named "CyclomicsSeq"- a novel ctDNA (circulating tumor DNA is
tumor-derived fragmented DNA in the bloodstream that is not associated with
cells) detection assay based on Oxford Nanopore sequencing which delivers fast,
low-cost, and point-of-care sequencing. In contrast to available ctDNA-based
methods, "CyclomicsSeq" ensures that even a single ctDNA molecule in the blood
can be detected at very high accuracy. This solution consists of a new
diagnostic kit (CyclomicsSeq), which has been licensed to Oxford Nanopore (LON:
ONT), an RNA/DNA next-generation sequencing platform company.
Cyclomics' Omni-Omic 4th generation technology, we believe, will disrupt the
cancer diagnostics market and clinical practice by enabling fast and reliable
results and delivering superior performance to standard radiological and
physical examination alone. The platform enables reliable, fast, and ultra-
sensitive early/ recurrence detection of cancer using the next-generation whole
genome sequencing. That is achieved by detecting ctDNA, a reliable biomarker for
determining the presence or absence of cancer, which can be non-invasively
obtained from a blood sample (liquid biopsy). The novel approach to cancer
detection is based on a single vial of blood and multi-dimensional profiling.
Cyclomics applies a wide multi-signal/ multi-omics approach to a very low amount
of tumor ctDNA. The Omni-Omic approach is critical for early cancer detection
with high accuracy.
Radiological imaging is the current standard in detecting tumor recurrence, but
it suffers from low sensitivity and specificity, very often revealing relapsed
cancer when it has progressed too far for effective treatment strategies. Fast,
non-invasive treatment response monitoring is critical for cancer patients to
timely adjust drug doses or change drug choices.
Cyclomics has already developed an early detection technology called
"CyclomicsSeq TP53", an in vitro diagnostic (IVD) kit integrating an innovative
sequencing methodology and state-of-the-art analysis software. Ninety percent of
Head Neck Cancer (HNC) patients carry specific oncogenic DNA mutations in the
gene TP53. There are 150,000 new cases every year in the EU and nearly 70,000 in
the USA. The Cyclomics solution can be applied to other cancer types harboring
TP53, such as small-cell lung cancer, squamous cell lung cancer, triple-negative
breast cancer, and high-grade serous ovarian cancer, and can be expanded to
almost all cancer types.
GEDiCube is committed to the early detection of cancer, to intervene at a stage
where treatment can be most effective. With its award-winning AI Technology
high, performing biomarker panels for 13 frequently occurring cancer types have
been discovered. The technology also significantly accelerates their development
and validation into diagnostic products through in-silico validation, saving
valuable development time and money. The focus is on early cancer- and early
recurrence detection, prediction of response to therapy, and personalized
treatment, all via liquid biopsy tests. Our platform, "The Cube," brings
together proprietary artificial intelligence (AI/ML) technology and algorithms,
multi-omics, multi-modal data, and the expertise of a carefully selected
multidisciplinary team.
GEDiCube's platform technology deploys next-generation AI running on NVIDIA's
latest chips and stacks genetic and protein expression on top of DNA mutation
for accuracy in cancer detection. GEDiCube is focused on developing advanced
diagnostic and monitoring tests that use multi-omics, integrating data from each
stage of genetic expression, including genomics, epigenomics, transcriptomics,
proteomics, fragmentomics, and metabolomics. As a member of the Nvidia Inception
Program, the company will integrate medical imaging into its AI engine.
Upon closing, the combined companies will aim to accelerate entry into the
cancer monitoring market and gain access to integrating whole genome data into
GEDiCube's AI/Machine Learning platform.
"We are very excited about this new opportunity," said Alessio Marcozzi, PhD co-
founder of Cyclomics. "Our Omni-Omic technology was developed to help empower AI
platforms and thereby transform non-invasive healthcare solutions to detect
cancers and other diseases as early as possible. GEDiCube's innovative deep
learning algorithms have created robust multi-omics panels that perform
remarkably well. Together, I believe we will change the field."
Coenraad van Kalken, MD, PhD, the CEO of GEDiCube, commented, "There is enormous
power in applying AI to multiple omics data layers that can be detected from a
vial of blood from every patient with cancer. I believe that integrating
Cyclomics into GEDiCube will allow us to gain greater accuracy and widespread
Omni-omic measurements through next-generation sequencing and enter the cancer
monitoring market this year. I consider that to be a significant step towards
bringing early detection of cancer to its inflection point."
About Cyclomics
Cyclomics is a Dutch company founded in 2018, winner of the Health Holland
Venture Challenge (startup of the year) by scientists of the UMC Utrecht
(https://www.umcutrecht.nl/). Its ambition is to transform cancer care by
enabling faster and more reliable diagnoses, particularly in the context of
cancer recurrence, thanks to its proprietary circulating tumor DNA (ctDNA
(https://en.wikipedia.org/wiki/Circulating_tumor_DNA)) detection technology.
https://www.cyclomics.com/
About GEDiCube/ RenovaroCube
At GEDiCube/ RenovaroCube, we are committed to the early detection of cancer, to
intervene at a stage where treatment can be most effective. We have developed an
award-winning AI Technology that significantly accelerates early cancer
detection and diagnosis at an early stage and its recurrence via liquid biopsy.
Our platform, "The Cube," brings together proprietary artificial intelligence
(AI/ML) technology and algorithms, multi-omics, multi-modal data, and the
expertise of a carefully selected multidisciplinary team to accelerate precision
medicine and enable breakthrough changes in cancer care. As of this morning
GEDiCube will operate under its new name, RenovaroCube.
https://www.renovarocube.com
About Renovaro
Renovaro aims to accelerate precision, personalized medicine for longevity
powered by mutually reinforcing AI and biotechnology platforms for early
diagnosis, better-targeted treatments, and drug discovery. The Renovaro Group
includes RenovaroCube and Renovaro Biosciences. Renovaro Biosciences is an
advanced cell-gene immunotherapy company. Its lead candidate product is a
therapeutic vaccine targeting cancers that are difficult to treat, including
pancreatic and potentially HNC, triple-negative breast cancer, and advanced
liver cancer. However, the vaccine could potentially work for all solid tumors
and chronic infectious diseases such as HIV and Hepatitis B Virus.
https://www.renovarogroup.com
https://www.renovarobio.com
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similar expressions. Actual events or results may differ materially from those
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Contact: ir@renovarobio.com (mailto:ir@renovarobio.com)
Source: Renovaro Biosciences
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